Recent research has revealed direct actions of phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) on a diverse array of cellular functions including actin assembly and cytoskeletal dynamics, vesicular protein trafficking, protein kinase localization and activation, cell proliferation and apoptosis.
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