HUMAN PDGF-CC- PEPROTECH

• 产品编号：100-00CC-5ug      品牌：invitrogen       原厂货号：100-00CC-5UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > PDGF血小板衍生因子
• 应用分类：

描述：

肝素结合生长因子的血小板衍生的生长因子家族（PDGF）包括五个已知成员，PDGF-AA、PDGF-BB、PDGF-AB、PDGF-CC和PDGF-DD。成熟的有活性的蛋白形式是由反平行二硫键连接的两个12-14 kDa的二聚体，它们通过水解前体蛋白而获得，前体蛋白包括其N端CUB结构域和PDGF / VEGF同源结构域。PDGFs与两个相关的酪氨酸激酶受体相互作用，PDGFR-α和PDGFR-β相互作用，并且是有效的促进多种类型细胞的分裂，包括平滑肌细胞、结缔组织细胞、骨和软骨细胞以及某些肿瘤细胞。它们在许多生物过程发挥重要作用，包括增生、胚胎神经元发育和呼吸道上皮细胞的发育。成熟PDGFs存储在血小板α-颗粒中，被释放后的血小板活化。 PDGF-AA，-AB，-BB和-CC信号主要通过PDGF-Rα受体，而PDGF-DD几乎完全与PDGF-Rβ受体相互作用。重组人PDGF-CC是一个25kDa蛋白质，由两个相同的二硫键连接的114个氨基酸的多肽链。

原厂资料：

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-AA, PDGF-BB, PDGF-AB, PDGF-CC and PDGF-DD. The mature and active form of these proteins, an anti-parallel disulfide-linked dimer of two 12-14 kDa polypeptide chains, is obtained through proteolytic processing of biologically inactive precursor proteins, which contain an N-terminal CUB domain and a PDGF/VEGF homologous domain. The PDGFs interact with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β, and are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and certain tumor cells. They play an important role in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubules epithelial cell development. Mature PDGFs are stored in platelet α-granules and are released upon platelet activation. PDGF-AA, -AB, -BB and –CC signal primarily through the PDGF-Rα receptor, whereas PDGF-DD interacts almost exclusively with the PDGF-Rβ receptor. Recombinant human PDGF-CC is a 25kDa protein consisting of two identical disulfide-linked 114 amino-acid polypeptide chains.

注意事项：

仅用于研究。不适用于诊断或治疗。