Human GDF-5 (Formerly BMP-14)

• 产品编号：120-01-1000ug      品牌：Peprotech       原厂货号：120-01
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > TGF-beta 转化生长因子beta超家族
• 应用分类：细胞培养产品与服务 > 哺乳动物细胞培养 > 细胞因子 > 生长因子
  　　　　　细胞培养产品与服务 > 哺乳动物细胞培养 > 生长因子和纯化蛋白质 > 物种 > 人

描述：

GDF-5表达于在胚胎发育和出生后在关节软骨中的长骨。GDF-5的成熟和功能性的形式是由二硫键连接两个120个氨基酸的多肽链形成的同型二聚体。每个GDF-5单体作为C末端前体多肽来表达，包含一个27个氨基酸的信号肽和一个354氨基酸的前肽。重组人GDF-5是由二硫键连接两个120个氨基酸的多肽链形成的27.0 kDa的同型二聚体蛋白。

原厂资料：

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 354 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.

注意事项：

License: This product is produced solely by PeproTech Inc. under a license from Biopharm GmbH, Germany. Biopharm GmbH is not responsible for the quality or fitness for use of this product. It may be used only for research purposes and may neither be used in humans nor for veterinary purposes. This product may not be used for commercial purposes.

仅用于研究。不适用于诊断或治疗。