HUMAN FGF-23- PEPROTECH

• 产品编号：100-52-500ug      品牌：invitrogen       原厂货号：100-52-500UG
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > FGF 成纤维细胞生长因子
• 应用分类：细胞培养产品与服务 > 哺乳动物细胞培养 > 细胞因子 > 生长因子

描述：

FGF家族通过促进细胞增殖和分化在产前发育、出生后生长和发育过程中发挥核心作用。 FGF-23、FGF-21和FGF-19构成一个非典型的FGF亚家族，其配位体作为循环激素需要一个Klotho蛋白质的参与作为共同受体进行信号传导。 FGF-23是来源于骨的激素，作用于肾脏，调节体内磷酸盐平衡和维生素D的代谢。FGF-23的信号受体是一个的Klotho-FGFR1（IIIc）复合物，是肾中磷酸钠协同转运的主要调节因子和维生素D代谢酶CYP27B1和CYP24A1的关键调节因子。重组人FGF-23是含有228个氨基酸残基的25.5 kDa的球状蛋白。

原厂资料：

The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant human FGF-23 is a 22.5 kDa globular protein containing 228 amino acid residues.

注意事项：

仅用于研究。不适用于诊断或治疗。