描述：
Fibroblast growth factor 20 (FGF-20) is a member of the FGF gene family, which currently
contains 22 members. Based on its structure, it is further classified as an FGF-9 subfamily
member. All FGF family members are heparinbinding growth factors with a 120 amino acid
(aa) core FGF domain that exhibits a β-trefoil structure. The cDNA of FGF-20 predicts a 211
aa polypeptide without a canonical signal peptide sequence, a feature shared with other
members of this subfamily. Nevertheless, it is secreted with a molecular weight of 27 kDa.
FGF-20 is known to bind to heparin. No alternate splice forms have been reported. However,
three amino acid polymorphisms are known, and single nucleotide polymorphisms in
noncoding regions that may effect expression show a strong correlation with a risk of
developing Parkinson’s disease. Human FGF-20 shows 98% aa identity to bovine FGF-20 and
95% aa identity to both rat and mouse FGF-20. Within the FGF-9 subfamily, FGF-20 is 69%
and 63% aa identical to human FGF-9 and FGF-16, respectively. Human FGF-20 is reported to
be promiscuous in its selection of receptors which include FGF R1c, FGF R2c, FGF R3b, FGF
R3c and FGF R4. FGF-20 is expressed a variety of cells, including dopaminergic neurons,
fibroblasts, keratinocytes and breast epithelium, and multiple sites in the fetus. Finally, the
expression of FGF-20 and DKK1 is regulated by β-catenin duringdevelopment and
tumorigenesis, implying that FGF-20 may play a role in the oncogenesis induced by the Wnt
signaling pathway.
原厂资料：
Fibroblast growth factor 20 (FGF-20) is a member of the FGF gene family, which currently
contains 22 members. Based on its structure, it is further classified as an FGF-9 subfamily
member. All FGF family members are heparinbinding growth factors with a 120 amino acid
(aa) core FGF domain that exhibits a β-trefoil structure. The cDNA of FGF-20 predicts a 211
aa polypeptide without a canonical signal peptide sequence, a feature shared with other
members of this subfamily. Nevertheless, it is secreted with a molecular weight of 27 kDa.
FGF-20 is known to bind to heparin. No alternate splice forms have been reported. However,
three amino acid polymorphisms are known, and single nucleotide polymorphisms in
noncoding regions that may effect expression show a strong correlation with a risk of
developing Parkinson’s disease. Human FGF-20 shows 98% aa identity to bovine FGF-20 and
95% aa identity to both rat and mouse FGF-20. Within the FGF-9 subfamily, FGF-20 is 69%
and 63% aa identical to human FGF-9 and FGF-16, respectively. Human FGF-20 is reported to
be promiscuous in its selection of receptors which include FGF R1c, FGF R2c, FGF R3b, FGF
R3c and FGF R4. FGF-20 is expressed a variety of cells, including dopaminergic neurons,
fibroblasts, keratinocytes and breast epithelium, and multiple sites in the fetus. Finally, the
expression of FGF-20 and DKK1 is regulated by β-catenin duringdevelopment and
tumorigenesis, implying that FGF-20 may play a role in the oncogenesis induced by the Wnt
signaling pathway.
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