3-异丁基-1-甲基黄嘌呤(IBMX）3-Isobutyl-1-Methylxanthine

产品编号：0219526201 品牌：MP 原厂货号：0219526201
产品分类：克隆 > DNA/RNA修饰酶 > RNA酶抑制剂
应用分类：细胞分析 > 细胞分析应用 > 细胞健康检测 > 細胞凋亡

包装：

1 g

运保温度:

0°C

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描述：

IBMX
Crystalline
Inhibits cyclic-AMP phosphodiesterase.
Ref.: 1. Beavo, J.A., et al., Molec. Pharmacol., 6: 597, (1970). 2. Montague, W. and Cook, J.R., Biochem. J., 122: 115, (1971).

Description: IBMX has been shown to be a potent, non-specific inhibitor of adenosine 3',5'-cyclic monophosphate phosphodiesterase (cAMP PDE)⁴, significantly more effective than theophylline.^1,2,14,15,21 Also inhibits cGMP phosphodiesterases. IBMX inhibits cyclic nucleotide PDE with subsequent inhibition of cyclic nucleotide hydrolysis, resulting in accumulation of cyclic AMP and guanosine 3',5'-cyclic monophosphate.^11,20 In a study of cyclic AMP and insulin release by islets of Langerhans, IBMX at 1 mM caused a marked increase in the intracellular concentration of cyclic AMP in the presence of glucose.¹⁴
IBMX, when used at 0.05 mM, was 20-fold more effective than theophylline at stimulating lipolysis in fat cells.² It has been shown to promote the conversion of fibroblast cells into adipose cells, apparently without altering the amount of bromodeoxyuridine (BrdU) present in the DNA of the cells.¹⁶
The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis.^5,7,18
Other actions of IBMX:

- Inhibition of phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀ = 1.3 uM).⁹
- An adenosine receptor antagonist.^7,12
- Inhibits ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells.⁸
- Inhibits the growth of carcinoma cells both in vivo and in vitro in mice.¹⁰

3-异丁基-1-甲基黄嘌呤

用途： cAMP 和 cGMP 磷酸二脂酶的非专一性抑制剂。IBMX抑制了磷酸二脂酶，cAMP的增加激活了PKA ，其结果是减少增殖，增加分化和诱发凋亡。 IBMX抑制由苯肾上腺素诱导的色胺（来自于神经内分泌上皮细胞的减少粘液IC50: 1.3 μM）的减少。也作为腺苷受体拮抗剂。

英文名称: 3-ISOBUTYL-1-METHYLXANTHINE
英文同义词: IMX;MIX;IBMX;SC 2964;NSC 165960;3-Isobutyl-1-methylx;Methylisobutylxanthine;Isobutylmethylxanthine;Isobutyl-1-methylxanthine;3-isobutyl-1-methyl-xanthin

中文名称: IBMX, 3-异丁基-1-甲基黄嘌呤
中文同义词: 1-甲基-3-异丁基黄嘌呤;3-异丁基-1-甲基黄嘌呤;IBMX, 3-异丁基-1-甲基黄嘌呤;3-异丁基-1-甲基黄嘌呤(MIBX);3-异丁基-1-甲基黄嘌呤(-20℃);3-异丁基-1-甲基黄嘌呤 ≥99%(-20°C);3,7-二氢-3-异丁基-1-甲基-1H-嘌呤-2,6-二酮