Purified from mouse ascites fluids by affinity chromatography
Guaranteed Application *
WB, IHC, IF, FC
Suggested Dilutions
WB 1:1000~2000, IHC 1:50, IF 1:100, FLOW 1:100
Background
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]
Related Pathway
Cell cycle
原厂资料：
Gene Name
Homo sapiens Ran GTPase activating protein 1 (RANGAP1), transcript variant 2
Synonyms:
Fug1; RANGAP; SD
Immunogen
Full length human recombinant protein of human RANGAP1 (NP_002874) produced in HEK293T cell.
Purified from mouse ascites fluids by affinity chromatography
Guaranteed Application *
WB, IHC, IF, FC
Suggested Dilutions
WB 1:1000~2000, IHC 1:50, IF 1:100, FLOW 1:100
Background
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]
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