描述：
PDGF was originally discovered as a major mitogenic factor in serum but not in plasma.
PDGF is stored in platelet α granules and released upon platelet activation. Besides
megakaryocytes, other cell types, including endothelial cells, monocyte/macrophages,
vascular smooth muscle cells, fibroblasts, cytotrophoblasts and a variety of transformed
or neoplastic cells, have been shown to produce PDGF. PDGFs are disulfidelinked dimers.
The subunits of the PDGF dimers are homologous polypeptides designated PDGF-A and
PDGF-B chains. Natural PDGFs can exist either as homodimers (PDGF-AA, PDGF-BB) or
heterodimers (PDGF-AB). Although all three isoforms of PDGF exist in human platelets,
R&D Systems’ hPDGF consists predominantly of hPDGF-AB heterodimers. PDGF obtained
from porcine platelets contain only PDGF-BB homodimers.Two distinct PDGF receptors,
the αreceptor and the βreceptor, have been identified. The two receptors are structurally
related, with an extracellular portion containing five immunoglobulinlike domains, a single
transmembrane region, and an intracellular portion with a proteintyrosine kinase domain.
The αreceptor binds both the A and B chains with high affinity whereas the βreceptor binds
only the Bchain with high affinity. Receptor dimerization is induced upon ligand binding.
In addition to being a potent mitogen for cells of mesenchymal origin, PDGF has also been
shown to be a potent chemoattractant for mesenchymal cells, mononuclear cells and
neutrophils and has been reported to be important in the modification of cellular matrix
constituents.
原厂资料：
PDGF was originally discovered as a major mitogenic factor in serum but not in plasma.
PDGF is stored in platelet α granules and released upon platelet activation. Besides
megakaryocytes, other cell types, including endothelial cells, monocyte/macrophages,
vascular smooth muscle cells, fibroblasts, cytotrophoblasts and a variety of transformed
or neoplastic cells, have been shown to produce PDGF. PDGFs are disulfidelinked dimers.
The subunits of the PDGF dimers are homologous polypeptides designated PDGF-A and
PDGF-B chains. Natural PDGFs can exist either as homodimers (PDGF-AA, PDGF-BB) or
heterodimers (PDGF-AB). Although all three isoforms of PDGF exist in human platelets,
R&D Systems’ hPDGF consists predominantly of hPDGF-AB heterodimers. PDGF obtained
from porcine platelets contain only PDGF-BB homodimers.Two distinct PDGF receptors,
the αreceptor and the βreceptor, have been identified. The two receptors are structurally
related, with an extracellular portion containing five immunoglobulinlike domains, a single
transmembrane region, and an intracellular portion with a proteintyrosine kinase domain.
The αreceptor binds both the A and B chains with high affinity whereas the βreceptor binds
only the Bchain with high affinity. Receptor dimerization is induced upon ligand binding.
In addition to being a potent mitogen for cells of mesenchymal origin, PDGF has also been
shown to be a potent chemoattractant for mesenchymal cells, mononuclear cells and
neutrophils and has been reported to be important in the modification of cellular matrix
constituents.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
