PP5 Antibody

• 产品编号：CST-2289S      品牌：CST       原厂货号：2289S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PP5 Antibody能够识别内源性PP5总蛋白。该多克隆抗体是由合成的人源的针对PP5蛋白氨基末端的肽段免疫动物，采用蛋白A和多肽亲和层析技术纯化生产的。蛋白磷酸酶5 (PP5)是丝氨酸/苏氨酸磷酸酶家族的一员，该家族还包括PP1，PP2A和PP2B。PP5包含异性的氨基末端调节结构域，该结构域具有三个3-4肽重复序列(TPR)模体和一个羧基末端催化结构(1-3)。通过TPR结构域，PP5与一系列蛋白相互作用并被报道参与了各种信号转导途径，包括糖皮质激素受体信号，p53介导的生长捕获，氧化应激介导的细胞凋亡和离子辐射诱导的DNA损伤应答(4-8)。

1. Chen, M.X. and Cohen, P.T. (1997) FEBS Lett. 400, 136-140.
2. Andreeva, A.V. and Kutuzov, M.A. (1999) Cell. Signal. 11, 555-562.
3. Chinkers, M. Trends Endocrinol. Metab. 12, 28-32.
4. Zuo, Z. et al. (1998) J. Biol. Chem. 273, 12250-12258.
5. Morita, K. et al. (2001) EMBO J. 20, 6028-6036.
6. Silverstein, A.M. et al. (1997) J. Biol. Chem. 272, 16224-16230.
7. Ali, A. et al. (2004) Genes Dev. 18, 249-254.
8. Wechsler, T. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 1247-1252.

原厂资料：

Specificity / Sensitivity

PP5 Antibody detects endogenous levels of total PP5 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human PP5. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Protein phosphatase 5 (PP5) is a member of the serine/threonine phosphatase family that also includes PP1, PP2A and PP2B. PP5 uniquely contains an amino-terminal regulatory domain with three tetratricopeptide repeat (TPR) motifs and a carboxy-terminal catalytic domain (1-3). Through the TPR domain, PP5 interacts with a number of proteins and has been reported to be involved in diverse signal transduction pathways, including glucocorticoid receptor signaling, p53-mediated growth arrest, oxidative stress-mediated apoptosis and the response to ionizing radiation-induced DNA damage (4-8). 

1. Chen, M.X. and Cohen, P.T. (1997) FEBS Lett. 400, 136-140.
2. Andreeva, A.V. and Kutuzov, M.A. (1999) Cell. Signal. 11, 555-562.
3. Chinkers, M. Trends Endocrinol. Metab. 12, 28-32.
4. Zuo, Z. et al. (1998) J. Biol. Chem. 273, 12250-12258.
5. Morita, K. et al. (2001) EMBO J. 20, 6028-6036.
6. Silverstein, A.M. et al. (1997) J. Biol. Chem. 272, 16224-16230.
7. Ali, A. et al. (2004) Genes Dev. 18, 249-254.
8. Wechsler, T. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 1247-1252.

注意事项：

For Research Use Only. Not For Use In Diagnostic Procedures.

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody