mGluR1 (D5H10) Rabbit mAb

• 产品编号：CST-12551S      品牌：CST       原厂货号：12551S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

mGluR1 (D5H10) Rabbit mAb 兔单抗能够检测内源性的mGluR1总蛋白。该单克隆抗体是由合成的人源mGluR1蛋白亮氨酸(1105位)肽段免疫动物而制备的。代谢型谷氨酸受体1（mGluR1）是哺乳动物脑中的神经递质谷氨酸的一种G蛋白偶联受体（GPCR）。不同于离子型受体，代谢型受体自己不形成离子通道孔，但与离子通道有间接联系（1）。mGluR1和mGluR5均与磷脂酶C耦合，通过G蛋白介导的机制激活肌醇磷脂代谢。磷脂激活后，第二信使钙被释放，生成钙激活的氯电流。mGluR1和mGluR5以外的代谢型谷氨酸受体抑制腺苷酸环化酶（1-3）。mGluR1不与传统G蛋白偶联受体共享同源序列（1）。mGluR1形成二聚体，与突触可塑性以及长时程增强和长期抑郁有关。此外，mGluR1是各种精神和神经系统疾病的潜在的治疗靶点，包括精神分裂症，癫痫，帕金森病和阿尔茨海默病（4-6）。

1. Pin, J.P. et al. (1994) EMBO J 13, 342-8.
2. Sugiyama, H. et al. (1987) Nature 325, 531-3.
3. Hermans, E. and Challiss, R.A. (2001) Biochem J 359, 465-84.
4. Niswender, C.M. et al. (2005) Curr Top Med Chem 5, 847-57.
5. Pellicciari, R. and Costantino, G. (1999) Curr Opin Chem Biol 3, 433-40.
6. Olive, M.F. (2009) Curr Drug Abuse Rev 2, 83-989.

原厂资料：

Specificity / Sensitivity

mGluR1 (D5H10) Rabbit mAb recognizes endogenous levels of total mGluR1 protein.

mGluR1 (D5H10) Rabbit mAb 兔单抗能够检测内源性的mGluR1总蛋白。

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu1105 of human mGluR1 protein.

Background

Metabotropic glutamate receptor 1 (mGluR1) is a G protein-coupled receptor (GPCR) for the neurotransmitter glutamate in the mammalian brain. Unlike ionotropic receptors, metabotropic receptors do not form an ion channel pore themselves but are indirectly linked to ion channels (1). Both mGluR1 and mGluR5 are coupled to phospholipase C and activate inositol phospholipid metabolism via G protein-mediated mechanisms. Upon phosphatidylinositol activation, the second messenger calcium is released and generates a calcium-activated chloride current. Metabotropic glutamate receptors other than mGluR1 and mGluR5 inhibit adenylate cyclase (1-3). mGluR1 does not share sequence homology with conventional GPCRs (1). mGluR1 forms a homodimer and is linked to synaptic plasticity, as well as long-term potentiation and long-term depression. Furthermore, mGluR1 is a potential therapeutic target for various psychiatric and neurological diseases, including schizophrenia, epilepsy, and Parkinson and Alzheimer diseases (4-6).

1. Pin, J.P. et al. (1994) EMBO J 13, 342-8.
2. Sugiyama, H. et al. (1987) Nature 325, 531-3.
3. Hermans, E. and Challiss, R.A. (2001) Biochem J 359, 465-84.
4. Niswender, C.M. et al. (2005) Curr Top Med Chem 5, 847-57.
5. Pellicciari, R. and Costantino, G. (1999) Curr Opin Chem Biol 3, 433-40.
6. Olive, M.F. (2009) Curr Drug Abuse Rev 2, 83-989.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.