Na/K ATPase Bta 3 Pure 46 150ug

产品编号：BD-610993 品牌：BD-Pharmingen 原厂货号：610993
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

150ug

运保温度:

Store undiluted at -20°C.

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描述：

Na+,K+-ATPase is an integral plasma membrane protein that maintains the intracellular concentrations of Na+ and K+ ions. It is a P class

pump that is composed of two α and two β transmembrane subunits. It is also thought to contain a

γ subunit. The 120 kDa α subunit

represents the catalytic site. Although the 50 kDa β subunit mediates proper folding of newly synthesized α subunits, it is not directly involved in ion transfer. There are four known αisoforms (

α1,α2,α3, andα4) and threeβisoforms (β1,β2, andβ3). The Na+,K+-ATPase is

ubiquitously expressed in the plasma membrane. However, the individual subunits have different tissue distributions:α1 is ubiquitous;α2 is in

skeletal muscle, brain, and heart;α3 is in brain and heart;α4 is present in testis and skeletal muscle;

β1 is in most tissues; andβ2 is primarily inneural tissues. Different combinations of theα and β

subunits can alter the kinetics of enzyme activity. The Na+,K+-ATPase transfers three

Na+ ions out of, and two K+ ions into, the cell upon hydrolysis of one ATP molecule. Maintenance of intracellular Na+,K+ levels is necessary

for volume regulation, action potentials, and secondary active transport

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.