Inhibins are dimeric peptide hormones produced by female ovarian granulose cells and male Sertoli cells as well as a variety of other tissues. Inhibins have two isoforms, A and B, with the same alpha subunit but different beta subunits. Inhibin A is a dimer of alpha and beta A subunits, inhibin B is a dimer of alpha and beta B subunits.
Inhibins are thought to inhibit the production of follicle-stimulating hormone (FSH) by the pituitary gland. In addition, Inhibins are also thought to play a role in the control of gametogenesis, and embryonic and fetal development.
Activin-A Human Recombinant also called Inhibin-Beta A chain produced in E.Coli is a single monomeric, non-glycosylated, polypeptide chain containing 116 amino acids fragment (311-426) and having an amino-terminal hexa-histidine tag, having a total molecular weight of 17.47 kDa.
The Activin-A is purified by standard chromatographic techniques.
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