Human Klotho

• 产品编号：100-53-1000ug      品牌：Peprotech       原厂货号：100-53
• 产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 细胞因子和生长因子 > 其它细胞因子和生长因子
• 应用分类：

描述：

Klotho是在细胞起着调节磷酸盐和钙稳态作用的糖基化蛋白。人类的Klotho存在膜结合型和分泌型的两种形式，主要表达在肾小管中，较少量的在脑、生殖器官、内分泌腺体、膀胱、骨骼肌、胎盘和结肠中表达。重组人Klotho是包含516个氨基酸残基的糖蛋白，还原条件下经SDS-PAGE分析其表观分子量为65-70 kDa。重组人Klotho计算出的分子量为58.6 kDa。

原厂资料：

Klotho is a glycosylated protein that plays an important role in the regulation of phosphate and calcium homeostasis. Human Klotho exists in both membrane bound and secreted forms, and is predominantly expressed in the kidney convoluted tubules, and to a lesser extent, in the brain, reproductive organs, endocrine glands, urinary bladder, skeletal muscle, placenta, and colon,. The full length transmembrane form has a large extracellular domain composed of two homologous subunits termed KL1 and KL2, which contain 516 and 439 amino acid residues, respectively, The predominant circulating form, which is derived from alternative RNA splicing, contains the KL1 subunit and constitutes the N-terminal sequence of transmembrane Klotho. A third Klotho protein of about 128 kDa has been identified in the blood and cerebrospinal fluid. This circulating protein arises from the action of an as yet unidentified protease which cleaves transmembrane Klotho just above and/or within the plasma membrane. Klotho has been shown to play a key role in the signaling cascade of fibroblast growth factor-23 (FGF-23), a bone derived hormone that acts in the kidney to inhibit phosphate reabsorption and vitamin D biosynthesis. Klotho promotes FGF-23 signaling through binding to FGFRI (IIIc) which converts this canonical FGF receptor into a specific receptor for FGF-23. In the absence of Klotho the function of FGF-23 is literally abolished. Recombinant human Klotho is a 65-70 kDa glycoprotein containing 516 amino acid residues.

注意事项：

仅用于研究。不适用于诊断或治疗。