Recombinant Human BMP-2/BMP-7 Heterodimer Protein, CF (10 UG)

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at ambient temperature

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描述：

Human BMP-7, also known as osteogenic protein -1 (OP-1), and BMP-2 are members of

the BMP subgroup of the TGF-β superfamily and signal through heterodimeric complexes

composed of type I and type II BMP receptors. BMP-2 and BMP-7 influence a variety of

morphogenic processes, particularly during skeletal and renal development.The human

BMP-2 cDNA encodes a 396 amino acid (aa) precursor that contains a 23 aa signal sequence,

a 259 propeptide, and a 114 aa mature protein. The human BMP-7 cDNA encodes a 431 aa

precursor that contains a 29 aa signal sequence, a 263 aa propeptide, and a 139 aa mature

protein. BMP propeptides are removed by proteolysis, enabling mature BMPs to form active

disulfide linked homodimers or heterodimers. Human and mouse BMP-2 and BMP-7 are 100%

and 98% identical, respectively, at the amino acid level. Human BMP-2 shares 85% aa sequence

identity with human BMP-4 and less than 51% aa sequence identity with other BMPs. Human

BMP-7 shares approximately 60%-70% aa sequence identity with BMP-5, -6, and -8, and less

than 50% aa sequence identity with other BMPs. BMP-2 and BMP-7 are coexpressed in some

embryonic tissues and associate into a functional 38 kDa osteogenic dimer. In in vitro osteoblast

differentiation assays and in vivo bone formation models, a BMP-2/BMP-7 heterodimer is

significantly more potent than either homodimer. Considering that BMP-2 preferentially binds

BMPRIA/ALK-3 and BMPRIB/ALK-6, while BMP-7 is selective for ALK-2, the observed increase in

heterodimer activity may be due to the triggering of additional receptor subtypes.

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