描述：
CXC chemokine ligand 16 (CXCL16) is a type I membrane protein containing a nonELR
Motif containing CXC chemokine domain in its extracellular region. Together with
Fractalkine (CX3CL1), CXCL16 constitute the only two transmembrane chemokines
within the superfamily. The gene for human CXCL16 predicts a 273 amino acid (aa)
residue precursor protein with a putative signal peptide, a CXC chemokine domain,
a mucinlike spacer region, a transmembrane domain and a cytoplasmic domain with
a potential tyrosine phosphorylation and SH2 proteinbinding site. Mouse and human
CXCL16 share 70% aa sequence similarity within their chemokine domains and 49%
overall aa sequence identity. By northern blot analysis, CXCL16 expression is detected
in various human organs except for brain, bone marrow, skeletal muscle or colon. By
flow cytometry, CXCL16 has been detected on the surface of CD19+ B cells, CD14+
monocytes/macrophages, and CD11c+ splenic and lymph node dendritic cells. Functional
CXCL16 can be shed from the cell surface as an approximately 35 kDa soluble protein.
The functional receptor for CXCL16 has been identified as CXCR6 (also known as Bonzo,
STRL33 or TYMSTR), a receptor previously shown to be a coreceptor for HIV entry. CXCL16
has also been independently cloned and named SRPSOX (scavenger receptor that binds
phosphatidylserine and oxidized lipoprotein).It was shown to be a specific receptor for
OxLDL but not LDL oracetylLDL.
原厂资料：
CXC chemokine ligand 16 (CXCL16) is a type I membrane protein containing a nonELR
Motif containing CXC chemokine domain in its extracellular region. Together with
Fractalkine (CX3CL1), CXCL16 constitute the only two transmembrane chemokines
within the superfamily. The gene for human CXCL16 predicts a 273 amino acid (aa)
residue precursor protein with a putative signal peptide, a CXC chemokine domain,
a mucinlike spacer region, a transmembrane domain and a cytoplasmic domain with
a potential tyrosine phosphorylation and SH2 proteinbinding site. Mouse and human
CXCL16 share 70% aa sequence similarity within their chemokine domains and 49%
overall aa sequence identity. By northern blot analysis, CXCL16 expression is detected
in various human organs except for brain, bone marrow, skeletal muscle or colon. By
flow cytometry, CXCL16 has been detected on the surface of CD19+ B cells, CD14+
monocytes/macrophages, and CD11c+ splenic and lymph node dendritic cells. Functional
CXCL16 can be shed from the cell surface as an approximately 35 kDa soluble protein.
The functional receptor for CXCL16 has been identified as CXCR6 (also known as Bonzo,
STRL33 or TYMSTR), a receptor previously shown to be a coreceptor for HIV entry. CXCL16
has also been independently cloned and named SRPSOX (scavenger receptor that binds
phosphatidylserine and oxidized lipoprotein).It was shown to be a specific receptor for
OxLDL but not LDL oracetylLDL.
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