描述：
Eotaxin2, also named myeloid progenitor inhibitory factor (MPIF2),
is a member of the CC chemokine subfamily and is designated CCL24.
Eotaxin2 is constitutively expressed in the jejunum and spleen.
It can also be induced in the lung by allergen challenge and IL4.
LPS and IL4 also differentially regulate the expression of
Eotaxin2 in monocytes and macrophages.
Mouse Eotaxin2 cDNA encodes a 119 amino acid (aa)
residue precursor protein that shares approximately 58% aa sequence
identity with human Eotaxin2.
Functionally, Eotaxin2 is most closely related to Eotaxin/CCL11 and Eotaxin3/CCL26.
The three proteins share low sequence homology but have been shown to be
potent eosinophil chemoattractants that bind and activate the chemokine receptor CCR3,
a receptor that is highly expressed in eosinophils.
Eotaxin2 also has the ability to suppress myeloid cell proliferation,
a biological function not shared by Eotaxin.
Two aminoterminallytruncated isoforms of mouse Eotaxin2 have been produced at R&D Systems.
The Val27 Val119 mouse Eotaxin2 isoform has been shown to be
150fold more potent than the Ile24 Val119
isoform as a chemoattractant for mouse BaR/3 cells transfected with mouse CCR3.
原厂资料：
Eotaxin2, also named myeloid progenitor inhibitory factor (MPIF2),
is a member of the CC chemokine subfamily and is designated CCL24.
Eotaxin2 is constitutively expressed in the jejunum and spleen.
It can also be induced in the lung by allergen challenge and IL4.
LPS and IL4 also differentially regulate the expression of
Eotaxin2 in monocytes and macrophages.
Mouse Eotaxin2 cDNA encodes a 119 amino acid (aa)
residue precursor protein that shares approximately 58% aa sequence
identity with human Eotaxin2.
Functionally, Eotaxin2 is most closely related to Eotaxin/CCL11 and Eotaxin3/CCL26.
The three proteins share low sequence homology but have been shown to be
potent eosinophil chemoattractants that bind and activate the chemokine receptor CCR3,
a receptor that is highly expressed in eosinophils.
Eotaxin2 also has the ability to suppress myeloid cell proliferation,
a biological function not shared by Eotaxin.
Two aminoterminallytruncated isoforms of mouse Eotaxin2 have been produced at R&D Systems.
The Val27 Val119 mouse Eotaxin2 isoform has been shown to be
150fold more potent than the Ile24 Val119
isoform as a chemoattractant for mouse BaR/3 cells transfected with mouse CCR3.
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