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MS X P21WAF1 (HJ21) 100 UG BIOSOURCE (TM)

 
包装:
运保温度: 4° C
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描述:

 

Details
Tested species reactivity Human , Mouse , Rat
Published species reactivity Artificial Control , Human , Mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Clone HJ21
Immunogen Human recombinant p21WAF1 protein.
Conjugate Unconjugated
Form Liquid
Purification purified
Storage buffer PBS, pH 7.4, with 0.2% BSA
Contains 0.09% sodium azide
Storage Conditions 4° C
Tested Applications Dilution *
Flow Cytometry (Flow) 3-5 µg/million cells
Immunofluorescence (IF) Assay Dependent
Immunohistochemistry (IHC) Assay Dependent
Western Blot (WB) Assay-Dependent

* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

Published Applications  
Immunocytochemistry (ICC) See 1 publications below
Western Blot (WB) See 2 publications below

Background/Target Information

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

 


注意事项:


For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.


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