FADD (pS194) Pure J119-857.36 100ug

• 产品编号：BD-558370      品牌：BD-Pharmingen       原厂货号：558370
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation.
The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor (TNF)
receptor type I (TNFRI, CD120a) and TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2, DR5) can trigger cell death, as well as
various other responses. Fas, TNFRI, and TRAILR2 affect a common target in the cell death pathway, FADD (Fas-Associated via Death
Domain or FAS-Associating protein with Death Domain, also known as MORT1). FADD is an adaptor protein that specifically binds to Fas
and other death domain-containing proteins via their homologous death domains. FADD also contains an N-terminal Death Effector Domain
(DED) that interacts with the DED-containing procaspases-8 and -10 to initiate apoptosis. The role of FADD serine 194 (S194)
phosphorylation in the regulation of apoptosis and cell cycle progression is under investigation.

原厂资料：

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. .
3.Store undiluted at 4°C .