Hu MRP-1 Pure QCRL-3 100ug

产品编号：BD-557594 品牌：BD-Pharmingen 原厂货号：557594
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

100ug

运保温度:

Store undiluted at 4°C.

到货周期：

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描述：

Reacts with an intracellular epitope of the multidrug resistance protein (MRP1). MRP1 is a 190 kDa integral membrane phosphoglycoprotein,
member of the ATP-binding cassette transporter proteins, overexpressed in some drug-selected resistant cell lines and has been shown to cause
multidrug resistance in transfected cells. Clone QCRL-3 was generated using non-denatured membranes from H69AR, an
MRP1-overexpressing, multidrug resistant, drug-selected cell line. Its epitope has been localized to the first nucleotide binding domain of
MRP1 between amino acids 617 and 932.3 QCRL-3 does not cross-react with human MDR1 or MDR3 gene products, nor with murine
MRP1. It is reported that mAb QCRL-3 inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vesicles.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C.