Ms CD56 Pure 12F11 100ug

包装：

运保温度:

Store undiluted at 4°C.

到货周期：

登录后查看

标准价：

￥客户可见

会员价：

￥客户可见

积分：

客户可见分

登录之后可加入购物车购买，请您

运费与支付说明：

1.含干冰类产品有运费；

2. 必须现金付款或有信用额度的会员才可以直接发货，否则需要等待现金付款信息。

描述：

CD56 or N-CAM (Neural cell adhesion molecule) is a member of a family of adhesion molecules including L1, contactin, TAG-1 and others,

which mediate neuronal attachment, process extension and cell-cell interaction(s) in the central nervous system (CNS). N-CAM has been

shown to play a role during the development and maintenence of synaptic connectivity of the hippocampus, as well as other organs within the

CNS. In addition to facilitating cell adhesive properties, N-CAM may play a role signal transduction pathways. N-CAM can participate in

regulation of astrocyte proliferation via a mechanism which involves the mitogen-activated protein kinase (MAPK) pathway. N-CAM

associates directly with L1 to form a complex which participates in signal pathways promoting neurite outgrowth. N-CAM exists in several

isoforms which result from alternative splicing of mRNA. These isoforms contain posttranslational modifications such as addition of polysialic

residues and carbohydrate epitopes. Embryonic N-CAM (~200-230 kD) is highly sialylated; whereas adult N-CAM isoforms (~120, 140 and

180 kD) are less so, yet are more adhesive. These modifications, along with the diversity of local distribution of the isoforms, may contribute

to distinct roles for these forms. Adult N-CAM isoforms of 120, 140 and 180 kDa are observed by SDS-PAGE.

Clone 12F11 recognizes an intracellular epitope of N-CAM and has been shown to react with human, rat, mouse, and chick N-CAM. The

antibody specifically recognizes the 140 and 180 kDa isoforms of N-CAM, but does not recognize the 120 kDa isoform. Higher molecular

weight (MW) isoforms may also be observed, particularly in samples from embryonic brain tissue.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before

discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.Store undiluted at 4°C.