Hu Cyclin B1 PE Set GNS-1 100Tst

• 产品编号：BD-550783      品牌：BD-Pharmingen       原厂货号：550783
• 产品分类：抗体 > 一抗 > 抗体对
• 应用分类：

原厂资料：

Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes.
Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. The main
cyclin-cdks complexes formed in vertebrae cells are cyclin-cdks complexes that regulate the progression of the cell cycle. The main
cyclin-cdks complexes formed in vertebrae cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1
(G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory
proteins including p21 and p27[Kip1]. Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl
and SV40) large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb) nucleolin and others. Cyclin B1 is a mitotic cyclin complex;
expression is normally low in G0/G1, increases in S, and is maximal during G2/M. Cyclin B1 is rapidly degraded at the end of mitosis and is
required for cells to exit from mitosis. Clone GNS-1 recognizes an epitope between amino acids 1-21 of human Cyclin B1. GNS-1 crossreacts
with hamster and mouse cyclin B1 by western blot analysis; however, it has not been evaluated for crossreactivity by flow cytometry.
Recombinant human cyclin B1 was used as immunogen.

注意事项：

1.This antibody has been optimized and preassayed with its matched isotype control to be used at the recommended volume of 20 ul/test.
Titration of the reagents or substituting with other (non-matched) isotype control is NOT recommended.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before
discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze .