Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells.
Additional information: Clone REA630 displays negligible binding to Fc receptors.
Alternative names
U-PAR, uPAR
原厂资料：
V16Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells.
Additional information: Clone REA630 displays negligible binding to Fc receptors.
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