Clone REA621 recognizes the CD134 (OX40) antigen, a member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. CD134 is a 50 kDa type I membrane glycoprotein expressed by activated T lymphocytes. The interaction of CD134 with OX40L has been implicated in T cell–dependent humoral response, regulation of primary T cell expansion, survival of T cells, size of the memory T cell pool, and regulation of tolerance in the CD4+ T cell compartment. It is reported, that CD134 activates NF-κB through its interaction with adaptor proteins TRAF2 and TRAF5.
Additional information: Clone REA621 displays negligible binding to Fc receptors.
Alternative names
OX-40, OX40
原厂资料：
Clone REA621 recognizes the CD134 (OX40) antigen, a member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. CD134 is a 50 kDa type I membrane glycoprotein expressed by activated T lymphocytes. The interaction of CD134 with OX40L has been implicated in T cell–dependent humoral response, regulation of primary T cell expansion, survival of T cells, size of the memory T cell pool, and regulation of tolerance in the CD4+ T cell compartment. It is reported, that CD134 activates NF-κB through its interaction with adaptor proteins TRAF2 and TRAF5.
Additional information: Clone REA621 displays negligible binding to Fc receptors.
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