Clone REA578 recognizes the Rae-1α/β/γ antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1α/β/γ were detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells in vivo. Clone REA578 does not detect Rae-1δ/ε.
Additional information: Clone REA578 displays negligible binding to Fc receptors.
Alternative names
Mrnp41
原厂资料：
Clone REA578 recognizes the Rae-1α/β/γ antigen, a surface protein and member of GPI-linked (glypiated) proteins which share partial homology with MHC class I molecules. Rae-1α/β/γ were detected in early mouse embryos, especially in the head region. Rae-1 is also up-regulated on a large variety of tumor cells. Together with H-60, Rae-1 is a ligand for the murine NKG2D receptor and a potent stimulator of innate immunity. The ligand-expressing tumour cells induce potent priming of cytotoxic T cells and sensitization of NK cells in vivo. Clone REA578 does not detect Rae-1δ/ε.
Additional information: Clone REA578 displays negligible binding to Fc receptors.
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