Phosphatidylinositol 3-kinase catalytic subunit type 3
hVps34
Phosphoinositide-3-kinase class 3
Phosphatidylinositol 3-kinase p100 subunit
PtdIns-3-kinase type 3
PI3K type 3
PI3-kinase type 3
Background Information
PI3-kinase type 3 (also known as VPS34 or PIK3C3) is a member of the phosphatidylinositide 3-kinase family and plays a role in phosphoinositide lipid metabolism. PI3-kinase type 3 may be important in the pathogenesis of schizophrenia. PI3-kinase type 3 has also been found to regulate many different portions in the endosomal and autophagic pathways. A PI3-kinase type 3 deficiency has shown severe failing in cell proliferation and embryogenesis, missing the mesoderm development.
Product Information
Format
Purified
Control
NIH3T3 cell lysate
Presentation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application
Anti-PI3-kinase type 3 Antibody, clone 17D1.1 detects level of PI3-kinase type 3 & has been published & validated for use in WB & IC.
Key Applications
Western Blotting
Immunocytochemistry
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human PI3-kinase type 3.
Clone
17D1.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis.
CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
COFACTOR: Manganese.
SUBUNIT STRUCTURE: Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive.
SUBCELLULAR LOCATION: Midbody.
TISSUE SPECIFICITY: Ubiquitously expressed, with a highest expression in skeletal muscle.
SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in NIH3T3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected PI3-kinase type 3 on 10 µg of NIH3T3 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H, R, M
WB, ICC
M
Purified
Monoclonal Antibody
Description
Catalogue Number
05-1563
Description
Anti-PI3-kinase type 3 Antibody, clone 17D1.1
Alternate Names
Phosphatidylinositol 3-kinase catalytic subunit type 3
hVps34
Phosphoinositide-3-kinase class 3
Phosphatidylinositol 3-kinase p100 subunit
PtdIns-3-kinase type 3
PI3K type 3
PI3-kinase type 3
Background Information
PI3-kinase type 3 (also known as VPS34 or PIK3C3) is a member of the phosphatidylinositide 3-kinase family and plays a role in phosphoinositide lipid metabolism. PI3-kinase type 3 may be important in the pathogenesis of schizophrenia. PI3-kinase type 3 has also been found to regulate many different portions in the endosomal and autophagic pathways. A PI3-kinase type 3 deficiency has shown severe failing in cell proliferation and embryogenesis, missing the mesoderm development.
Product Information
Format
Purified
Control
NIH3T3 cell lysate
Presentation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application
Anti-PI3-kinase type 3 Antibody, clone 17D1.1 detects level of PI3-kinase type 3 & has been published & validated for use in WB & IC.
Key Applications
Western Blotting
Immunocytochemistry
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human PI3-kinase type 3.
Clone
17D1.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis.
CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
COFACTOR: Manganese.
SUBUNIT STRUCTURE: Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive.
SUBCELLULAR LOCATION: Midbody.
TISSUE SPECIFICITY: Ubiquitously expressed, with a highest expression in skeletal muscle.
SEQUENCE SIMILARITIES: Belongs to the PI3/PI4-kinase family. Contains 1 PI3K/PI4K domain.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in NIH3T3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected PI3-kinase type 3 on 10 µg of NIH3T3 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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