Retinoid X receptor α (RXRA or RXR alpha) is a nuclear receptor that mediates the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRs as a whole exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulate their transcription.
Product Information
Format
Purified
Control
MCF-7 cell lysate
Presentation
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-RXR alpha Antibody, clone 4E9 is a Mouse Monoclonal Antibody for detection of RXR α also known as Retinoid X receptor alpha & has been validated in WB, ICC.
Key Applications
Western Blotting
Immunocytochemistry
Application Notes
Immunocytochemistry: Representative lot data.
A 1:500 dilution of a previous lot detected Retinoid X Receptor α in A431 cells.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to Retinoid X Receptor α.
Clone
4E9
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq].
FUNCTION:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer By similarity.
SUBUNIT STRUCTURE:Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with FAM120B By similarity. Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6. Interacts with DNTTIP2. Interacts with RNF8.
SUBCELLULAR LOCATION:Nucleus.
TISSUE SPECIFICITY:Highly expressed in liver, also found in lung, kidney and heart.
DOMAIN:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM:Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
SEQUENCE SIMILARITIES:Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Product Usage Statements
Quality Assurance
Evaluated by western blot on MCF-7 cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Retinoid X Receptor α in MCF-7 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8ºC from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H
WB, ICC
M
Purified
Monoclonal Antibody
Description
Catalogue Number
05-1359
Description
Anti-RXR alpha Antibody, clone 4E9
Alternate Names
Nuclear receptor subfamily 2 group B member 1
retinoid X receptor, alpha
Retinoid X receptor alpha
Background Information
Retinoid X receptor α (RXRA or RXR alpha) is a nuclear receptor that mediates the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRs as a whole exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulate their transcription.
Product Information
Format
Purified
Control
MCF-7 cell lysate
Presentation
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-RXR alpha Antibody, clone 4E9 is a Mouse Monoclonal Antibody for detection of RXR α also known as Retinoid X receptor alpha & has been validated in WB, ICC.
Key Applications
Western Blotting
Immunocytochemistry
Application Notes
Immunocytochemistry: Representative lot data.
A 1:500 dilution of a previous lot detected Retinoid X Receptor α in A431 cells.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to Retinoid X Receptor α.
Clone
4E9
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq].
FUNCTION:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer By similarity.
SUBUNIT STRUCTURE:Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with FAM120B By similarity. Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6. Interacts with DNTTIP2. Interacts with RNF8.
SUBCELLULAR LOCATION:Nucleus.
TISSUE SPECIFICITY:Highly expressed in liver, also found in lung, kidney and heart.
DOMAIN:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM:Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
SEQUENCE SIMILARITIES:Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Product Usage Statements
Quality Assurance
Evaluated by western blot on MCF-7 cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Retinoid X Receptor α in MCF-7 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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