Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
Product Information
Format
Affinity Purified
Control
Human pancreas tissue.
Presentation
The monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Applications
Application
Anti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
Biosynthetic human insulin
Clone
MAB1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
This antibody recognizes an epitope including the amino acid B30.
FUNCTION:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. SUBUNIT STRUCTURE:Heterodimer of a B chain and an A chain linked by two disulfide bonds. SUBCELLULAR LOCATION:Secreted. INVOLVEMENT IN DISEASE:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. PHARMACEUTICAL USE:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. SEQUENCE SIMILARITIES:Belongs to the insulin family. SEQUENCE CAUTION:The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: 1.25 µg/mL of this antibody detected insulin in human pancreas tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at 2-8°C and use within 1 year from date of receipt.
Packaging Information
Material Size
1 mg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H
IH(P)
M
Affinity Purified
Monoclonal Antibody
Description
Catalogue Number
05-1108
Replaces
CBL71
Description
Anti-Insulin Antibody, clone1
Background Information
Insulin is a polypeptide hormone that regulates carbohydrate metabolism. Apart from being the primary agent in carbohydrate homeostasis, it has effects on fat metabolism.
Product Information
Format
Affinity Purified
Control
Human pancreas tissue.
Presentation
The monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application.
Applications
Application
Anti-Insulin Antibody, clone1 is an antibody against Insulin for use in IH(P).
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
Biosynthetic human insulin
Clone
MAB1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
This antibody recognizes an epitope including the amino acid B30.
FUNCTION:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. SUBUNIT STRUCTURE:Heterodimer of a B chain and an A chain linked by two disulfide bonds. SUBCELLULAR LOCATION:Secreted. INVOLVEMENT IN DISEASE:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730]. PHARMACEUTICAL USE:Available under the names Humulin or Humalog (Eli Lilly) and Novolin (Novo Nordisk). Used in the treatment of diabetes. Humalog is an insulin analog with 52-Lys-Pro-53 instead of 52-Pro-Lys-53. SEQUENCE SIMILARITIES:Belongs to the insulin family. SEQUENCE CAUTION:The sequence AAA59179.1 differs from that shown. Reason: Erroneous gene model prediction.
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human pancreas tissue.
Immunohistochemistry Analysis: 1.25 µg/mL of this antibody detected insulin in human pancreas tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Store at 2-8°C and use within 1 year from date of receipt.
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