Interleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies.
Product Information
Format
Purified
Control
MiCK-2™ cells
Presentation
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application
This Anti-Interleukin 4 (IL-4) Antibody, clone 11.B.11 is validated for use in FC, EA for the detection of Interleukin 4 (IL-4).
Key Applications
Flow Cytometry
Enzyme Assay
Application Notes
Functional Activity Assay: A previous lot was utilized by an independent laboratory to show increased resistance of mice to Listeria monocytogenes infection after administration of anti-interleukin 4 (IL-4), clone 11.B.11. (Haak-Frendscho, M., et al., 1992).
Biological Information
Immunogen
Recombinant protein corresponding to mouse IL-4.
Epitope
Unknown
Clone
11B11
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in MiCK-2™ cells.
Flow Cytometry Analysis: 10 µg of this antibody detected IL-4 in MiCK-2™ cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M
FC, EA
R
Purified
Monoclonal Antibody
Description
Catalogue Number
04-964
Description
Anti-Interleukin 4 (IL-4) Antibody, clone 11.B.11
Alternate Names
B cell growth factor 1
interleukin 4
Lymphocyte stimulatory factor 1
B_cell stimulatory factor 1
B-cell stimulatory factor 1
Background Information
Interleukin-4 (IL-4) is a cytokine that stimulates activated B-cell and T-cell proliferation and induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. These Th2 cells, in turn, also produce IL-4. IL-4 also acts as a key regulator in humoral and adaptive immunity and induces B-cell class switching to IgE, as well as up-regulating MHC class II production. Mutations in the IL-4 gene may lead to a susceptibility to ischemic stroke or cerebral infarction. Overproduction of IL-4 is associated with allergies.
Product Information
Format
Purified
Control
MiCK-2™ cells
Presentation
Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Applications
Application
This Anti-Interleukin 4 (IL-4) Antibody, clone 11.B.11 is validated for use in FC, EA for the detection of Interleukin 4 (IL-4).
Key Applications
Flow Cytometry
Enzyme Assay
Application Notes
Functional Activity Assay: A previous lot was utilized by an independent laboratory to show increased resistance of mice to Listeria monocytogenes infection after administration of anti-interleukin 4 (IL-4), clone 11.B.11. (Haak-Frendscho, M., et al., 1992).
Biological Information
Immunogen
Recombinant protein corresponding to mouse IL-4.
Epitope
Unknown
Clone
11B11
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
FUNCTION: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-4/IL-13 family.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in MiCK-2™ cells.
Flow Cytometry Analysis: 10 µg of this antibody detected IL-4 in MiCK-2™ cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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