100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
Applications
Application
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect IRAK3 using this Anti-IRAK3 Antibody, rabbit validated for use in IP & WB.
Key Applications
Western Blotting
Immunoprecipitation
Application Notes
Immunoblot Analysis: A 1:2,000 dilution of the lot detected IRAK3 CT in lysates from A431 cells.
Immunoprecipitation:
A 1:50 dilution of this antibody immunoprecipitated IRAK3 CT using protein G:agarose beads.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to residues in the C-term of human IRAK-3
FUNCTION:SwissProt: Q9Y616 # Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). COFACTOR:Magnesium. SIZE:596 amino acids; 67753 Da TISSUE SPECIFICITY:Expressed predominantly in peripheral blood lymphocytes. DISEASE:SwissProt: Q9Y616 # Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. SIMILARITY:SwissProt: Q9Y616 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
2 years at -20°C from date of shipment
Packaging Information
Material Size
100 µL
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M, H
WB, IP
Rb
Purified
Monoclonal Antibody
Description
Catalogue Number
04-367
Brand Family
Upstate
Trade Name
Upstate
Description
Anti-IRAK3 Antibody, rabbit monoclonal
Alternate Names
IRAKM
Product Information
Format
Purified
Presentation
100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
Applications
Application
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Detect IRAK3 using this Anti-IRAK3 Antibody, rabbit validated for use in IP & WB.
Key Applications
Western Blotting
Immunoprecipitation
Application Notes
Immunoblot Analysis: A 1:2,000 dilution of the lot detected IRAK3 CT in lysates from A431 cells.
Immunoprecipitation:
A 1:50 dilution of this antibody immunoprecipitated IRAK3 CT using protein G:agarose beads.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to residues in the C-term of human IRAK-3
FUNCTION:SwissProt: Q9Y616 # Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). COFACTOR:Magnesium. SIZE:596 amino acids; 67753 Da TISSUE SPECIFICITY:Expressed predominantly in peripheral blood lymphocytes. DISEASE:SwissProt: Q9Y616 # Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis. SIMILARITY:SwissProt: Q9Y616 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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