IL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity.
Product Information
Format
Purified
Control
PC3 cells
Presentation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application
Anti-IL-18 Antibody, clone 12E7.1 is an antibody against IL-18 for use in IH, FC.
Key Applications
Flow Cytometry
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in human tonsil tissue.
Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in inflamed skin and normal human spleen tissues.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human IL-18.
Clone
12E7.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq].
FUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-1 family.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in PC3 cells.
Flow Cytometry Analysis: 1 µg of this antibody detected IL-18 in PC3 cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M, H
FC, IHC
M
Purified
Monoclonal Antibody
Description
Catalogue Number
04-1585
Description
Anti-IL-18 Antibody, clone 12E7.1
Alternate Names
Interferon gamma-inducing factor
interleukin 18 (interferon-gamma-inducing factor)
IL-1 gamma
IFN-gamma-inducing factor
iboctadekin
interleukin-18
Interleukin-1 gamma
Iboctadekin
Background Information
IL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity.
Product Information
Format
Purified
Control
PC3 cells
Presentation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Applications
Application
Anti-IL-18 Antibody, clone 12E7.1 is an antibody against IL-18 for use in IH, FC.
Key Applications
Flow Cytometry
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in human tonsil tissue.
Immunohistochemistry Analysis: 1:250 from a previous lot detected IL-18 in inflamed skin and normal human spleen tissues.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human IL-18.
Clone
12E7.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq].
FUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
SUBCELLULAR LOCATION: Secreted.
SEQUENCE SIMILARITIES: Belongs to the IL-1 family.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in PC3 cells.
Flow Cytometry Analysis: 1 µg of this antibody detected IL-18 in PC3 cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
