Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.
Product Information
Format
Purified
Control
BALB/c splenocytes
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.
Key Applications
Neutralizing
Flow Cytometry
Immunoprecipitation
Western Blotting
Application Notes
Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Biological Information
Immunogen
Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.
Epitope
Extracellular Domain
Clone
MARI-5A3
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
This antibody recognizes the extracellular domain of IFNAR-1.
FUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in BALB/c splenocytes.
Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size
100 µg
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
M
NEUT, FC, IP, WB
M
Purified
Monoclonal Antibody
Description
Catalogue Number
04-151
Description
Anti-IFNAR-1 Antibody, clone MARI-5A3
Alternate Names
human interferon-alpha receptor (HuIFN-alpha-Rec)
interferon alpha/beta receptor 1
IFN-alpha/beta receptor 1
interferon-alpha/beta receptor alpha chain
IFN-alpha-REC
Cytokine receptor class-II member 1
interferon-beta receptor 1
Cytokine receptor family 2 member 1
Type I interferon receptor 1
alpha-type antiviral protein
beta-type antiviral protein
interferon (alpha, beta and omega) receptor 1
interferon alpha/beta receptor 1
Background Information
Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.
Product Information
Format
Purified
Control
BALB/c splenocytes
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.
Key Applications
Neutralizing
Flow Cytometry
Immunoprecipitation
Western Blotting
Application Notes
Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
Biological Information
Immunogen
Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1.
Epitope
Extracellular Domain
Clone
MARI-5A3
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Specificity
This antibody recognizes the extracellular domain of IFNAR-1.
FUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.
Contains 3 fibronectin type-III domains.
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in BALB/c splenocytes.
Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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