hnRNP K (Heterogeneous nuclear ribonucleoprotein K) is a pre-mRNA binding protein. It is a component of hnRNP complexes that act as substrates for pre-mRNA processing prior to translation in the cytoplasm. hnRNP K is ubiquitously expressed in both the cytoplasm and the nucleus. hnRNP K acts as transcriptional regulator and functions in nucleocytoplasmic shuttling. hnRNP K is modified by phosphorylation (PKC δ, c-Src), methylation, and acetylation, and its expression and function are increased by epidermal growth factor (EGF).
Product Information
Format
Ascites
Control
HeLa cell lysate
Presentation
Mouse ascites IgG1k in buffer containing 0.05% sodium azide.
Applications
Application
This Anti-hnRNP K Antibody, clone F45P9C7 is validated for use in WB for the detection of hnRNP K.
Key Applications
Western Blotting
Application Notes
Western Blot Analysis: A 1:2000 dilution of this lot detected hnRNP K in HeLa cell lysate. Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 450 to the C-terminus of human hnRNP K
Epitope
C-Terminus
Clone
clone F45P9C7
Host
Mouse
Specificity
Antibody strongly detects a single band at ~62 kDa, corresponding to hnRNP K
Isotype
IgG1κ
Species Reactivity
Human
Species Reactivity Note
Reacts with human.
Predicted to react with mouse, rat, chicken, and rabbit, due to sequence homology.
Routinely evaluated by western blot on HeLa cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size
100 µL
原厂资料：
Key Spec Table
Species Reactivity
Key Applications
Host
Format
Antibody Type
H
WB
M
Ascites
Monoclonal Antibody
Description
Catalogue Number
04-088
Brand Family
Upstate
Trade Name
Upstate
Description
Anti-hnRNP K Antibody, clone F45P9C7
Background Information
hnRNP K (Heterogeneous nuclear ribonucleoprotein K) is a pre-mRNA binding protein. It is a component of hnRNP complexes that act as substrates for pre-mRNA processing prior to translation in the cytoplasm. hnRNP K is ubiquitously expressed in both the cytoplasm and the nucleus. hnRNP K acts as transcriptional regulator and functions in nucleocytoplasmic shuttling. hnRNP K is modified by phosphorylation (PKC δ, c-Src), methylation, and acetylation, and its expression and function are increased by epidermal growth factor (EGF).
Product Information
Format
Ascites
Control
HeLa cell lysate
Presentation
Mouse ascites IgG1k in buffer containing 0.05% sodium azide.
Applications
Application
This Anti-hnRNP K Antibody, clone F45P9C7 is validated for use in WB for the detection of hnRNP K.
Key Applications
Western Blotting
Application Notes
Western Blot Analysis: A 1:2000 dilution of this lot detected hnRNP K in HeLa cell lysate. Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 450 to the C-terminus of human hnRNP K
Epitope
C-Terminus
Clone
clone F45P9C7
Host
Mouse
Specificity
Antibody strongly detects a single band at ~62 kDa, corresponding to hnRNP K
Isotype
IgG1κ
Species Reactivity
Human
Species Reactivity Note
Reacts with human.
Predicted to react with mouse, rat, chicken, and rabbit, due to sequence homology.
Routinely evaluated by western blot on HeLa cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
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