Long Name: Nur-related Factor 1/Nerve Growth Factor Induced B beta/Nuclear Receptor Subfamily 4, Group A, 2
Aliases: NGFI-B beta; NOT; NR4A2; TINUR
Entrez Gene IDs: 4929 (Human); 18227 (Mouse)
Background: Nurr1
Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr 1 is important for specification of dopaminergic neurons that degenerate in Parkinson's disease. Human and mouse Nurr1 share 99% amino acid sequence homology.
原厂资料：
Molecule Information: Nurr1/NGFI-B beta/NR4A2
Long Name: Nur-related Factor 1/Nerve Growth Factor Induced B beta/Nuclear Receptor Subfamily 4, Group A, 2
Aliases: NGFI-B beta; NOT; NR4A2; TINUR
Entrez Gene IDs: 4929 (Human); 18227 (Mouse)
Background: Nurr1
Nurr1 belongs to the nerve growth factor-induced clone B subfamily of nuclear receptor superfamily and is designated NR4A2 in the Unified Nomenclature System for NRs. Nurr1 can function as a ligand-independent transcription factor. Nurr1 also heterodimerizes with retinoid X receptors (RXRs) to function as ligand-regulated transcription factor. Nurr 1 is important for specification of dopaminergic neurons that degenerate in Parkinson's disease. Human and mouse Nurr1 share 99% amino acid sequence homology.
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