描述：
FGF basic (FGF-2, HBGF-2) is one of at least 22 mitogenic proteins of the FGF family, which
show 35 -60% amino acid conservation . Unlike other FGFs, FGF acidic and basic lack signal
peptides and are secreted by an alternate pathway. Storage pools within the cell or on cell
surface heparan sulfate proteoglycans (HSPG) are likely. The predicted 17 kDa FGF basic
isoform can be located in both the cytoplasm and the nucleus and is presumed to be the form
secreted. Transcription from alternate start sites produces 21-24 kDa forms found only in the
nucleus. High and low molecular weight human FGF basic targets the expression of different
genes when expressed in NIH-3T3 cells .The 17 kDa mouse sequence has 98% aa identity with
rat, and 95% identity with human, bovine and sheep FGF basic. Autocrine, intracrine and
paracrine actions of FGF basic have been identified. Binding of FGF to heparin or cell surface
HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors.
FGF basic binds other proteins, polysaccharides and lipids with lower affinity. Expression of
FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively
mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates
such normal processes as angiogenesis, wound healing and tissue repair, embryonic
development and differentiation, neuronal function and neural degeneration. Transgenic
overexpression of FGF basic results in excessive proliferation and angiogenesis reminiscent
of a variety of pathological conditions.
原厂资料：
FGF basic (FGF-2, HBGF-2) is one of at least 22 mitogenic proteins of the FGF family, which
show 35 -60% amino acid conservation . Unlike other FGFs, FGF acidic and basic lack signal
peptides and are secreted by an alternate pathway. Storage pools within the cell or on cell
surface heparan sulfate proteoglycans (HSPG) are likely. The predicted 17 kDa FGF basic
isoform can be located in both the cytoplasm and the nucleus and is presumed to be the form
secreted. Transcription from alternate start sites produces 21-24 kDa forms found only in the
nucleus. High and low molecular weight human FGF basic targets the expression of different
genes when expressed in NIH-3T3 cells .The 17 kDa mouse sequence has 98% aa identity with
rat, and 95% identity with human, bovine and sheep FGF basic. Autocrine, intracrine and
paracrine actions of FGF basic have been identified. Binding of FGF to heparin or cell surface
HSPG is necessary for binding, dimerization and activation of tyrosine kinase FGF receptors.
FGF basic binds other proteins, polysaccharides and lipids with lower affinity. Expression of
FGF basic is nearly ubiquitous but disruption of the mouse FGF basic gene gives a relatively
mild phenotype, suggesting compensation by other FGF family members. FGF basic modulates
such normal processes as angiogenesis, wound healing and tissue repair, embryonic
development and differentiation, neuronal function and neural degeneration. Transgenic
overexpression of FGF basic results in excessive proliferation and angiogenesis reminiscent
of a variety of pathological conditions.
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