描述：
Cardiotrophin-like cytokine (CLC), (also known as novel neurotrophin-1 (NNT-1) and B cell
stimulating factor (BSF3) is a 22 -25 kDa member of the IL-6 family of cytokines. As such,
it is expressed as a long, type I cytokine with four α-helices in its structure. Human CLC is
synthesized as a 225 amino acid (aa) precursor that contains a 27 aa signal sequence and a
198 aa mature region. It contains one potential N-linked glycosylation site that is apparently
utilized, and two distinct binding sites for Ciliary Neurotrophic Factor Receptor alpha (CNTF Rα)
and Cytokine Receptorlike Factor (CLF). Although CLC has a signal sequence, it is not secreted
unless noncovalently complexed to either CLF or soluble CNTF Rα. Once complexed, CLC signals
through a tripartite receptor complex composed of gp130, LIF Rβ and CNTF Rα. Within the IL6
family, human CLC is most homologous to cardiotrophin1, sharing approximately 29% amino
acid sequence identity. Human to mouse, mature CLC shares 96% aa sequence identity. CLC is a
trophic factor for motor neurons, a stimulator of ACTH release from corticotrophs, and an
inducer of IgE synthesis and B cell proliferation. Cells known to express CLC include embryonic
muscle, lung epithelium, and mesenchyme in various regions.
原厂资料：
Cardiotrophin-like cytokine (CLC), (also known as novel neurotrophin-1 (NNT-1) and B cell
stimulating factor (BSF3) is a 22 -25 kDa member of the IL-6 family of cytokines. As such,
it is expressed as a long, type I cytokine with four α-helices in its structure. Human CLC is
synthesized as a 225 amino acid (aa) precursor that contains a 27 aa signal sequence and a
198 aa mature region. It contains one potential N-linked glycosylation site that is apparently
utilized, and two distinct binding sites for Ciliary Neurotrophic Factor Receptor alpha (CNTF Rα)
and Cytokine Receptorlike Factor (CLF). Although CLC has a signal sequence, it is not secreted
unless noncovalently complexed to either CLF or soluble CNTF Rα. Once complexed, CLC signals
through a tripartite receptor complex composed of gp130, LIF Rβ and CNTF Rα. Within the IL6
family, human CLC is most homologous to cardiotrophin1, sharing approximately 29% amino
acid sequence identity. Human to mouse, mature CLC shares 96% aa sequence identity. CLC is a
trophic factor for motor neurons, a stimulator of ACTH release from corticotrophs, and an
inducer of IgE synthesis and B cell proliferation. Cells known to express CLC include embryonic
muscle, lung epithelium, and mesenchyme in various regions.
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