描述：
B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the
dominant costimulatory pathways that regulate T-and B-cell responses. Although
both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2
with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of
the immune response. B7-1 is expressed on activated B cells, activated T cells, and
macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans
cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through
interferon γ. B7-1 and B7-2 are both members of the Immunoglobulin superfamily. Human
B7-1 is a 288 amino acid (aa) protein containing a 34 aa signal peptide, a 208 aa extracellular
domain, a 21 aa transmembrane domain, and a 25 aa cytoplasmic domain. Human B7-1 and
B7-2 share 26% amino acid identity. Human and mouse B7-1 share 44% amino acid identity.
However, it has been observed that both human and mouse B7-1 and B7-2 can bind to either
human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which
form theB7-1/B7-2/CD28/CTLA-4 critical binding sites.
原厂资料：
B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the
dominant costimulatory pathways that regulate T-and B-cell responses. Although
both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2
with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of
the immune response. B7-1 is expressed on activated B cells, activated T cells, and
macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans
cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through
interferon γ. B7-1 and B7-2 are both members of the Immunoglobulin superfamily. Human
B7-1 is a 288 amino acid (aa) protein containing a 34 aa signal peptide, a 208 aa extracellular
domain, a 21 aa transmembrane domain, and a 25 aa cytoplasmic domain. Human B7-1 and
B7-2 share 26% amino acid identity. Human and mouse B7-1 share 44% amino acid identity.
However, it has been observed that both human and mouse B7-1 and B7-2 can bind to either
human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which
form theB7-1/B7-2/CD28/CTLA-4 critical binding sites.
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