描述：
OX40, also known as CD134, was originally identified as an activated rat CD4+ T cellsurface
antigen that is recognized by the monoclonal antibody MRC OX40. It is amember of the tumor
necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF4. Mouse OX40
cDNA encodes a 256 amino acid (aa) residues type I transmembrane precursor protein with a
putative 19 aa signal peptide, a 192 aa extracellular domain containing 4 TNFRcysteine rich
repeats, a 25 aa transmembrane domain and a 36 aa cytoplasmic region. A naturally occurring
soluble OX40 has also been identified in human serum. Mouse OX40 shares approximately 63%
and 90% aa sequence identity with its human and rat counterparts, respectively. OX40 is a T cell
activation antigen that is expressed primarily on activated CD4+ T cells, but is also expressed
on activated human and mouse CD8+ T cells. The ligand of OX40 is OX40 ligand (OX40L), also
known as gp34, a type II transmembrane glycoprotein belonging to the TNF superfamily.
OX40L is expressed on activated B cells, T cells, dendritic cells and endothelial cells. Ligation of
OX40 on T cells by OX40L or an agonistic antibody can promote clonal expansion, longterm
T cell survival, and enhance memory T cell development. In vivo, blockade of OX40/OX40L
interaction has been useful for treating autoimmune disease and graftversushost disease
in animal models. Activation of OX40 has also been utilized to enhance the potency of vaccines
and augment antitumor immunity.
原厂资料：
OX40, also known as CD134, was originally identified as an activated rat CD4+ T cellsurface
antigen that is recognized by the monoclonal antibody MRC OX40. It is amember of the tumor
necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF4. Mouse OX40
cDNA encodes a 256 amino acid (aa) residues type I transmembrane precursor protein with a
putative 19 aa signal peptide, a 192 aa extracellular domain containing 4 TNFRcysteine rich
repeats, a 25 aa transmembrane domain and a 36 aa cytoplasmic region. A naturally occurring
soluble OX40 has also been identified in human serum. Mouse OX40 shares approximately 63%
and 90% aa sequence identity with its human and rat counterparts, respectively. OX40 is a T cell
activation antigen that is expressed primarily on activated CD4+ T cells, but is also expressed
on activated human and mouse CD8+ T cells. The ligand of OX40 is OX40 ligand (OX40L), also
known as gp34, a type II transmembrane glycoprotein belonging to the TNF superfamily.
OX40L is expressed on activated B cells, T cells, dendritic cells and endothelial cells. Ligation of
OX40 on T cells by OX40L or an agonistic antibody can promote clonal expansion, longterm
T cell survival, and enhance memory T cell development. In vivo, blockade of OX40/OX40L
interaction has been useful for treating autoimmune disease and graftversushost disease
in animal models. Activation of OX40 has also been utilized to enhance the potency of vaccines
and augment antitumor immunity.
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