Recombinant Human JAM-A Fc Chimera Protein, CF (50 UG)

产品编号：RD-1103-JM-050 品牌：R&D 原厂货号：1103-JM-050
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描述：

Molecule Information: JAM-A

Long Name: Junctional Adhesion Molecule A

Aliases: CD321; F11R; PAM-1

Entrez Gene IDs: 50848 (Human); 16456 (Mouse)

Background: JAMs (Junctional Adhesion Molecules)
Members of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.

原厂资料：

Protein Construct:

Human JAM-A (Ser28 - Ala242) Accession # Q9Y624	IEGRMD	Human IgG₁ (Pro100 - Lys330)
N-terminus		C-terminus

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

Reconstitution:
Reconstitute at 100 µg/mL in sterile PBS.

Shipping:
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
3 months, -20 to -70 °C under sterile conditions after reconstitution.