描述：
The plateletderived growth factor (PDGF) family consists of proteins derived
from four genes (PDGFA, B, C, and D) that form four disulfidelinked homodimers
(PDGFAA, BB, CC, and DD) and one heterodimer (PDGFAB).
These proteins regulate diverse cellular functions by binding to and inducing
the homoor heterodimerization of two receptors (PDGF Rα and Rβ).
Whereas α/α homodimerization is induced by PDGFAA, BB, CC,
and AB, α/β heterodimerization is induced by PDGFAB,BB, CC,
and DD, and β/β homodimerization is induced only by PDGFBB,
and DD. Both PDGF Rα and Rβ are members of the class III subfamily of receptor
tyrosine kinases (RTK) that have five immunoglobulinlike domains in their
extracellular region and a split kinase domain in their intracellular region.
Ligandinduced receptor dimerization results in autophosphorylation in transresulting
in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, cell migration and
extracellular matrix production. Rat PDGFA chain cDNA encodes a 204 amino acid (aa)
residue precursor protein with a 20 aa signal peptide, a 65 aa propeptide that
is removed by proteolysis, and a 119 aa mature protein. By alternative splicing,
a short form lacking 8 Cterminal aa residues also exists. The long form contains
the 8 aa basic insert which promotes intracellular cell retention and association with cell
matrix. PDGFA is expressed in multiple cell types and tissues. Based on PDGFA
knockout studies, PDGFA appears to be important for the development of
oligodendrocytes, testicular Leydig cells, alveolar smooth muscle cells, hair
follicles and intestinal villus.
原厂资料：
The plateletderived growth factor (PDGF) family consists of proteins derived
from four genes (PDGFA, B, C, and D) that form four disulfidelinked homodimers
(PDGFAA, BB, CC, and DD) and one heterodimer (PDGFAB).
These proteins regulate diverse cellular functions by binding to and inducing
the homoor heterodimerization of two receptors (PDGF Rα and Rβ).
Whereas α/α homodimerization is induced by PDGFAA, BB, CC,
and AB, α/β heterodimerization is induced by PDGFAB,BB, CC,
and DD, and β/β homodimerization is induced only by PDGFBB,
and DD. Both PDGF Rα and Rβ are members of the class III subfamily of receptor
tyrosine kinases (RTK) that have five immunoglobulinlike domains in their
extracellular region and a split kinase domain in their intracellular region.
Ligandinduced receptor dimerization results in autophosphorylation in transresulting
in the activation of several intracellular signaling pathways that can lead to cell proliferation, cell survival, cytoskeletal rearrangement, cell migration and
extracellular matrix production. Rat PDGFA chain cDNA encodes a 204 amino acid (aa)
residue precursor protein with a 20 aa signal peptide, a 65 aa propeptide that
is removed by proteolysis, and a 119 aa mature protein. By alternative splicing,
a short form lacking 8 Cterminal aa residues also exists. The long form contains
the 8 aa basic insert which promotes intracellular cell retention and association with cell
matrix. PDGFA is expressed in multiple cell types and tissues. Based on PDGFA
knockout studies, PDGFA appears to be important for the development of
oligodendrocytes, testicular Leydig cells, alveolar smooth muscle cells, hair
follicles and intestinal villus.
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