p42 MAP Kinase (MAPK)

产品编号：P6080L 品牌：New England Biolabs 原厂货号：P6080L
产品分类：蛋白质检测与分析 > 蛋白质，多肽和酶 > 蛋白激酶 > 其他
应用分类：

包装：

运保温度:

-70°C

到货周期：

登录后查看

标准价：

￥客户可见

会员价：

￥客户可见

积分：

客户可见分

登录之后可加入购物车购买，请您

运费与支付说明：

1.含干冰类产品有运费；

2. 必须现金付款或有信用额度的会员才可以直接发货，否则需要等待现金付款信息。

描述：

p42 MAP Kinase (Mitogen-Activated Protein Kinase, MAPK), also known as Erk2 (Extracellular signal-regulated kinase 2) is one of two isoforms of MAP kinase family. It is a serine/threonine protein kinase, participating in mammalian signal transduction pathways that control intracellular responses to hormones and major developmental changes. Full activation of p42 MAP Kinase requires phosphorylation at residues T183 and Y185 catalyzed by the upstream protein kinase MEK2 or MAP Kinase Kinase (MAPKK) (1-4).

Highlights

Protein serine/threonine kinase
Mouse, recombinant (E. coli)

Product Source

Isolated from a strain of E. coli that carries a clone expressing murine MAPK (1) under the control of a T7 expression system. Fully active MAPK is produced by co-expression with a constitutively active form of its activator, MEK2 (6).

Recognition Determinant

The minimal recognition motif for phosphorylation by MAPK is S/TP. Pro is also common at the -2 position in the optimal primary motif PXS/TP. The substrate specificity of MAPK overlaps with other proline-directed protein kinases present within the cell. This suggests that the recognition of protein substrates may require structural determinants in addition to primary sequence requirements (5).