CEND1 Antibody

• 产品编号：CST-9894S      品牌：Cell Signaling Technology       原厂货号：9894S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CEND1 Antibody 兔多抗识别内源性的总CEND1蛋白。该多克隆抗体由合成的人类 CEND1蛋白氨基末端附近肽段免疫动物而制成。该抗体使用蛋白A和多肽亲和层析纯化而得。祖细胞向神经细胞分化的过程受细胞周期调控，从增殖过渡为神经细胞分化。CEND1（cell cycle exit and neuronal differentiation 1，细胞周期出口和神经分化1）是一种神经细胞的蛋白质，广泛表达于成年神经系统中（1）。它与细胞同步化退出周期和发育中的神经系统里神经元前体分化有关，它的表达标志着增殖细胞退出细胞周期（2,3）。CEND1在成年神经系统的脑室下区的表达水平对新生儿的SVZ神经生长中调控细胞周期和神经分化是关键性的（4）。最近研究表明，神经祖细胞（NPCs）过度表达CEND1时脑损伤的小鼠模型中神经细胞的分化增加，表明其可能作为干预治疗神经退行性疾病和脑损伤的潜在方法（5）。

1. Patsavoudi, E. et al. (1995) J Neurosci Res 40, 506-18.
2. Politis, P.K. et al. (2007) Proc Natl Acad Sci USA 104, 17861-6.
3. Koutmani, Y. et al. (2004) Eur J Neurosci 20, 2509-23.
4. Katsimpardi, L. et al. (2008) Stem Cells 26, 1796-807.
5. Makri, G. et al. (2010) Stem Cells 28, 127-39.

原厂资料：

Specificity / Sensitivity

CEND1 Antibody recognizes endogenous levels of total CEND1 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CEND1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The progression of progenitor cells towards neuronal differentiation is regulated by cell cycle control and the transition from proliferative to neurogenic cell divisions. CEND1 (cell cycle exit and neuronal differentiation 1) is a neuronal protein widely expressed in the adult nervous system (1). It is implicated in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system, and its expression marks the exit of proliferative cells from the cell cycle (2,3). Levels of CEND1 expression in the subventricular zone of the adult nervous system are critical for cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis (4). It has recently been shown that neural progenitor cells (NPCs) that overexpress CEND1 display increased neuronal differentiation in a mouse model of brain injury, suggesting its potential use as a therapeutic intervention for neurodegenerative diseases and brain injury (5).

1. Patsavoudi, E. et al. (1995) J Neurosci Res 40, 506-18.
2. Politis, P.K. et al. (2007) Proc Natl Acad Sci USA 104, 17861-6.
3. Koutmani, Y. et al. (2004) Eur J Neurosci 20, 2509-23.
4. Katsimpardi, L. et al. (2008) Stem Cells 26, 1796-807.
5. Makri, G. et al. (2010) Stem Cells 28, 127-39.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.