Lyric/Metadherin (2F11C3) Mouse mAb

• 产品编号：CST-9596S      品牌：CST       原厂货号：9596S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Lyric/Metadherin (2F11C3)小鼠单抗检测内源性总Lyric/Metadherin蛋白水平。单抗由重组蛋白免疫动物产生，该重组蛋白特异对应人lyric/metadherin 蛋白的N氨基末端。Lyric/AEG-1（胶质细胞上调基因1）/ MTDH (Metadherin)也被确认为一种紧密连接（TJ）蛋白，根据它在极性上皮细胞中的定位（1）。不同亚细胞定位和Lyric/AEG-1/MTDH过表达已经在多种人类癌症中被发现。Lyric/AEG-1/MTDH涉及有关各种细胞功能包括增值和凋亡/存活的信号通路，在癌症中的变化与不良预后有关（综述2）。在乳腺癌中，增加的Lyric/AEG-1/MTDH可看作增加的化疗耐药和转移（3,4）。Lyric/AEG-1/MTDH表达在信号通路和肝癌细胞（HCC）疾病进程以及多形性成胶质细胞瘤中很重要（6）。

1. Britt, D.E. et al. (2004) Exp Cell Res 300, 134-48.
2. Hu, G. et al. (2009) Clin Cancer Res 15, 5615-20.
3. Brown, D.M. and Ruoslahti, E. (2004) Cancer Cell 5, 365-74.
4. Hu, G. et al. (2009) Cancer Cell 15, 9-20.
5. Yoo, B.K. et al. (2009) J Clin Invest 119, 465-77.
6. Emdad, L. et al. (2010) Mol Cancer Ther 9, 79-88.

原厂资料：

Specificity / Sensitivity

Lyric/Metadherin (2F11C3) Mouse mAb detects endogenous levels of total lyric/metadherin protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human lyric/metadherin protein.

Background

Lyric/AEG-1 (Astrocyte Elevated Gene 1)/MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium (1). 
 
 Differential subcellular localization and overexpression of Lyric/AEG-1/MTDH has been seen in multiple human cancers. Lyric/AEG-1/MTDH is involved in signaling pathways related to various cellular functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis (reviewed in 2). In breast cancer, increased Lyric/AEG-1/MTDH may confer increased chemoresistance as well as metastasis (3,4). Lyric/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellular carcinoma (HCC) (5) and glioblastoma multiforme (GBM) (6).

1. Britt, D.E. et al. (2004) Exp Cell Res 300, 134-48.
2. Hu, G. et al. (2009) Clin Cancer Res 15, 5615-20.
3. Brown, D.M. and Ruoslahti, E. (2004) Cancer Cell 5, 365-74.
4. Hu, G. et al. (2009) Cancer Cell 15, 9-20.
5. Yoo, B.K. et al. (2009) J Clin Invest 119, 465-77.
6. Emdad, L. et al. (2010) Mol Cancer Ther 9, 79-88.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.