CEND1 (D6A6) Rabbit mAb

• 产品编号：CST-8944S      品牌：CST       原厂货号：8944S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

CEND1 (D6A6) Rabbit mAb兔单抗能够检测内源性的CEND1总蛋白。该单克隆抗体是由合成的人源CEND1蛋白N末端肽段免疫动物而制备的。祖细胞向神经细胞分化的过程受细胞周期调控，从增殖过渡为神经细胞分化。细胞周期通道和神经细胞分化蛋白1 (CEND1)是一种神经细胞的蛋白质，广泛表达于成年神经系统中（1）。在神经系统的发育过程中，它关系着细胞周期退出与神经元前体分化的同步，它的表达标志着增殖细胞退出细胞周期（2,3）。新生儿的SVZ神经发生中，CEND1在成体神经系统的脑室下区的表达水平对调节细胞周期与神经分化是起着关键性的作用（4）。最近研究表明，在脑损伤的小鼠模型中，神经祖细胞（NPCs）过度表达CEND1时神经细胞的分化增加，表明这可能是一种干预治疗神经退行性疾病和脑损伤的潜在方法（5）。

1. Patsavoudi, E. et al. (1995) J Neurosci Res 40, 506-18.
2. Politis, P.K. et al. (2007) Proc Natl Acad Sci USA 104, 17861-6.
3. Koutmani, Y. et al. (2004) Eur J Neurosci 20, 2509-23.
4. Katsimpardi, L. et al. (2008) Stem Cells 26, 1796-807.
5. Makri, G. et al. (2010) Stem Cells 28, 127-39.

原厂资料：

Specificity / Sensitivity

CEND1 (D6A6) Rabbit mAb recognizes endogenous levels of total CEND1 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CEND1 protein.

Background

The progression of progenitor cells towards neuronal differentiation is regulated by cell cycle control and the transition from proliferative to neurogenic cell divisions. Cell cycle exit and neuronal differentiation 1 (CEND1) is a neuronal protein widely expressed in the adult nervous system (1). It is implicated in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system, and its expression marks the exit of proliferative cells from the cell cycle (2,3). Levels of CEND1 expression in the subventricular zone of the adult nervous system are critical for cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis (4). It has recently been shown that neural progenitor cells (NPCs) that overexpress CEND1 display increased neuronal differentiation in a mouse model of brain injury, suggesting its potential use as a therapeutic intervention for neurodegenerative diseases and brain injury (5).

1. Patsavoudi, E. et al. (1995) J Neurosci Res 40, 506-18.
2. Politis, P.K. et al. (2007) Proc Natl Acad Sci USA 104, 17861-6.
3. Koutmani, Y. et al. (2004) Eur J Neurosci 20, 2509-23.
4. Katsimpardi, L. et al. (2008) Stem Cells 26, 1796-807.
5. Makri, G. et al. (2010) Stem Cells 28, 127-39.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.