TEAD2 Antibody

• 产品编号：CST-8870S      品牌：Cell Signaling Technology       原厂货号：8870S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Specificity / Sensitivity

TEAD2 Antibody recognizes endogenous levels of total TEAD2 protein. This antibody does not cross-react with other TEAD family member proteins.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TEAD2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

原厂资料：

Specificity / Sensitivity

TEAD2 Antibody recognizes endogenous levels of total TEAD2 protein. This antibody does not cross-react with other TEAD family member proteins.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TEAD2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The Hippo pathway is an important evolutionarily conserved signaling pathway that controls organ size and tumor suppression by inhibiting cell proliferation and promoting apoptosis (1,2). An integral function of the Hippo pathway is to repress the activity of Yes-associated protein (YAP), a proposed oncogene whose activity is regulated by phosphorylation and subcellular localization (3,4). When the Hippo pathway is turned off, YAP is phosphorylated and translocates to the nucleus where it associates with various transcription factors including members of the TEF or Transcription Enhancer (TEAD) family (TEAD1-4) (5,6). Although widely expressed in tissues, the TEAD family proteins have specific tissue and developmental distributions. YAP/TEAD complexes regulate the expression of genes involved in cell proliferation and apoptosis (5).

1. Pan, D. (2010) Dev Cell 19, 491-505.
2. Harvey, K.F. et al. (2003) Cell 114, 457-67.
3. Zhao, B. et al. (2010) Genes Dev 24, 862-74.
4. Zhao, B. et al. (2008) Curr Opin Cell Biol 20, 638-46.
5. Zhao, B. et al. (2008) Genes Dev 22, 1962-71.
6. Zhao, B. et al. (2007) Genes Dev 21, 2747-61.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.