Dab2 Antibody

• 产品编号：CST-8582S      品牌：Cell Signaling Technology       原厂货号：8582S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Dab2抗体可以识别内源性总的Dab2蛋白。多抗由合成肽段免疫动物产生，该肽段与人Dab2 蛋白222位脯氨酸附近肽段序列一致。抗体由蛋白A和肽段亲和层析技术纯化得到。Dab2 (disabled homologue 2)是一种有丝分裂原应激磷酸蛋白。通过与大量蛋白结合，它发挥了多种功能。Dab2通过与蛋白结合，例如Smads 和TGF-β受体（1,2），axin（3），GRB (4),和 Src (5)调节多条信号通路（1,2）。Dab2也通过与clathrin (6), AP2 (7), NPXY-containing cargo (8-10), 和 Myosin VI (11,12)结合作为一种clathrin介导内吞作用的cargo特异性接头。除此以外，Dab2通过直接与整合素结合（13,14）调控细胞黏附。Dab2的不同功能使它协调细胞黏附，细胞运动，膜转运和信号通路。在多种癌症中Dab2表达下调，因此提示了它作为一种抑癌因子的作用（15-17）。Dab2磷酸化会降低它的内吞功能（18）。

原厂资料：

Specificity / Sensitivity

Dab2 Antibody recognizes endogenous levels of total Dab2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro222 of human Dab2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Dab2 (disabled homologue 2) is a mitogen responsive phosphoprotein. It exerts multiple functions through association with numerous proteins. Dab2 modulates various signaling pathways through interactions with proteins such as Smads and TGF-β receptors (1,2), axin (3), GRB (4), and Src (5). Dab2 also serves as a cargo-specific adaptor of clathrin-mediated endocytosis via interaction with clathrin (6), AP2 (7), NPXY-containing cargo (8-10), and Myosin VI (11,12). In addition, Dab2 regulates cell adhesion by directly binding integrins (13,14). The diverse functions of Dab2 enable it to coordinate cell adhesion, cell motility, membrane trafficking, and signaling. Dab2 is down-regulated in a number of cancers, thereby implicating its role as a tumor suppressor (15-17). Phosphorylation of Dab2 decreases its endocytotic function (18).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody