Glucagon (D16G10) XP? Rabbit mAb

• 产品编号：CST-8233P      品牌：Cell Signaling Technology       原厂货号：8233P
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Glucagon (D16G10) XP® Rabbit mAb兔单抗用于检测内源性胰高血糖素总蛋白水平。该单抗通过用与人源胰高血糖素蛋白Ala137 位点周围残基序列相同的合成肽免疫动物制备而得。糖代谢受到多种激素的调节，其中之一就是胰高血糖素。在胰岛α细胞中，胰高血糖素由其前体原胰高血糖素通过水解而生成。胰高血糖素可以促进糖元的分 解，并且可以促进肝脏的糖异生作用(1,2)。

1. Hers, H.G. and Hue, L. (1983) Annu. Rev. Biochem. 52, 617-653.
2. Granner, D. and Pilkis, S. (1990) J. Biol. Chem. 265, 10173-10176.

原厂资料：

Specificity / Sensitivity

Glucagon (D16G10) XP® Rabbit mAb recognizes endogenous levels of total glucagon protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala137 of human glucagon protein.

Background

Glucose homeostasis is regulated by a variety of hormones including glucagon. Glucagon is synthesized as the precursor molecule proglucagon and is proteolytically processed to yield the mature peptide in α cells of the pancreatic islets. Glucagon causes the release of glucose from glycogen and stimulates gluconeogenesis in the liver (1,2).

1. Hers, H.G. and Hue, L. (1983) Annu. Rev. Biochem. 52, 617-653.
2. Granner, D. and Pilkis, S. (1990) J. Biol. Chem. 265, 10173-10176.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.