Aldolase A (D73H4) Rabbit mAb

• 产品编号：CST-8060S      品牌：CST       原厂货号：8060S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

Aldolase A (D73H4) Rabbit mAb 能够检测内源性果糖二磷酸醛缩酶A总蛋白水平。该单克隆抗体是由合成的人源果糖二磷酸醛缩酶A蛋白脯氨酸(263位)肽段免疫动物制备的。醛缩酶（果糖二磷酸醛缩酶）是一种糖酵解酶，催化1,6-二磷酸果糖转化为3-磷酸甘油醛。这种无处不在的酶有三个不同的同工酶：醛缩酶A，醛缩酶B和醛缩酶C。研究表明醛缩酶A在非肿瘤性肝病及肝癌中有不同的表达量（1）。此外，在某些原发肿瘤病人中也观察到了醛缩酶B基因表达水平的变化（2,3）。

1. Castaldo, G. et al. (2000) Clin. Chem. 46, 901-906.
2. Kinoshita, M. and Miyata, M. (2002) Hepatology 36, 433-438.
3. Song, H. et al. (2004) World J. Gastroenterol 10, 509-513.

原厂资料：

Specificity / Sensitivity

Aldolase A (D73H4) Rabbit mAb recognizes endogenous levels of total fructose bisphosphate aldolase A protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro263 of human fructose bisphosphate aldolase A protein.

Background

Aldolase (fructose bisphosphate aldolase), a glycolytic enzyme, catalyzes the conversion of fructose 1, 6-bisphosphate to 3-phosphoglyceraldehyde. This ubiquitous enzyme is present as three different isozymes: aldolase A, aldolase B, and aldolase C. Research studies suggest that aldolase A expression potentially differentiates between nonneoplastic liver diseases and hepatocarcinoma (1). Furthermore, investigators have shown that changes in aldolase B gene expression levels have been observed in certain patients with this primary tumor (2,3).

1. Castaldo, G. et al. (2000) Clin. Chem. 46, 901-906.
2. Kinoshita, M. and Miyata, M. (2002) Hepatology 36, 433-438.
3. Song, H. et al. (2004) World J. Gastroenterol 10, 509-513.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody.