PANK2 Antibody (Mouse Specific)

• 产品编号：CST-6923S      品牌：CST       原厂货号：6923S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

PANK2 Antibody(小鼠特异性)用于检测内源性PANK2总蛋白水平。该多抗通过用与鼠源蛋白N端序列相同的合成肽免疫动物制备而来。抗体经Protein A和肽亲和层析纯化。泛酸激酶2（PANK2）在辅酶A合成的第一步中起催化反应（1,2）。人PANK2位于线粒体内，该基因的某些突变跟神经退行有关（2）。不同的是，小鼠的PANK2定位于胞浆中，该蛋白的缺陷会导致小鼠视网膜退化（1,2）。

1. Leonardi, R. et al. (2007) FEBS Lett 581, 4639-44.
2. Zhang, Y.M. et al. (2006) J Biol Chem 281, 107-14.
3. Kuo, Y.M. et al. (2005) Hum Mol Genet 14, 49-57.

原厂资料：

Specificity / Sensitivity

PANK2 Antibody (Mouse Specific) recognizes endogenous levels of total PANK2 protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse PANK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

PANK2, pantothenate kinase 2, catalyzes the first step in CoA biosynthesis (1, 2). Human PANK2 is located in the mitochondria, and some mutations in human PANK2 are linked to neurodegeneration (2). Alternatively, mouse PANK2 localizes in the cytosol, and defective PANK2 in mice leads to retinal degeneration (1, 2).

1. Leonardi, R. et al. (2007) FEBS Lett 581, 4639-44.
2. Zhang, Y.M. et al. (2006) J Biol Chem 281, 107-14.
3. Kuo, Y.M. et al. (2005) Hum Mol Genet 14, 49-57.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM
NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.
Do not aliquot the antibody.