ApoA4 (1D6B6) Mouse mAb

• 产品编号：CST-5700S      品牌：CST       原厂货号：5700S
• 产品分类：抗体 > 一抗 > 蛋白特异性一抗
• 应用分类：

描述：

ApoA4 (1D6B6)小鼠单克隆抗体识别内源性的全部ApoA4蛋白。该单克隆抗体用全长重组人ApoA4蛋白免疫动物而制成。载脂蛋白是血浆脂蛋白，可在血液循环系统中转运血脂和胆固醇。乳糜微粒是一种含有极低密度脂蛋白（VLDL），中间密度脂蛋白（IDL），低密度脂蛋白（LDL）和高密度脂蛋白（HDL）的载脂蛋白（1,2）。载脂蛋白A-IV（ApoA4）是一种糖蛋白，在人体血浆以自由载脂蛋白形式存在（3,4）。ApoA4激活卵磷脂胆固醇酰基转移酶（5-7），调节脂质转移蛋白（LTP）活性比率（7）。更多的证据表明，ApoA4也可以作为一种抗氧化剂，在动脉粥样硬化模型中抑制低密度脂蛋白氧化（8）。

1. Kwiterovich, P.O. (2000) Am J Cardiol 86, 5L-10L.
2. Hussain, M.M. (2000) Atherosclerosis 148, 1-15.
3. Utermann, G. and Beisiegel, U. (1979) Eur J Biochem 99, 333-43.
4. Hayashi, H. et al. (1990) J Lipid Res 31, 1613-25.
5. Steinmetz, A. and Utermann, G. (1985) J Biol Chem 260, 2258-64.
6. Chen, C.H. and Albers, J.J. (1985) Biochim Biophys Acta 836, 279-85.
7. Main, L.A. et al. (1996) Biochim Biophys Acta 1300, 17-24.
8. Wong, W.M. et al. (2007) Atherosclerosis 192, 266-74.

原厂资料：

Specificity / Sensitivity

ApoA4 (1D6B6) Mouse mAb recognizes endogenous levels of total ApoA4 protein.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant human ApoA4 protein.

Background

Apolipoproteins are plasma lipoproteins that function as transporters of lipids and cholesterol in the circulatory system. Chylomicrons are a fundamental class of apolipoproteins containing very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) (1,2).Apolipoprotein A-IV (ApoA4) is a glycoprotein that exists as a free apolipoprotein in human plasma (3,4). ApoA4 activates the lecithin cholesterol acyl transferase (5-7) to modulate the rate of lipid transfer protein (LTP) activity (7). Additional evidence suggests that ApoA4 may also act as an antioxidant to inhibit LDL oxidation in the atherosclerosis model (8).

1. Kwiterovich, P.O. (2000) Am J Cardiol 86, 5L-10L.
2. Hussain, M.M. (2000) Atherosclerosis 148, 1-15.
3. Utermann, G. and Beisiegel, U. (1979) Eur J Biochem 99, 333-43.
4. Hayashi, H. et al. (1990) J Lipid Res 31, 1613-25.
5. Steinmetz, A. and Utermann, G. (1985) J Biol Chem 260, 2258-64.
6. Chen, C.H. and Albers, J.J. (1985) Biochim Biophys Acta 836, 279-85.
7. Main, L.A. et al. (1996) Biochim Biophys Acta 1300, 17-24.
8. Wong, W.M. et al. (2007) Atherosclerosis 192, 266-74.

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody