PPP2R2A (2G9) Mouse mAb

产品编号：CST-5689S 品牌：CST 原厂货号：5689S
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

–20°C

到货周期：

登录后查看

标准价：

￥客户可见

会员价：

￥客户可见

积分：

客户可见分

登录之后可加入购物车购买，请您

运费与支付说明：

1.含干冰类产品有运费；

2. 必须现金付款或有信用额度的会员才可以直接发货，否则需要等待现金付款信息。

描述：

PPP2R2A (2G9) Mouse mAb能够识别内源性PPP2R2A/PP2A, B55-α/PR55-α总蛋白。该抗体与过表达的PPP2R4和PPP2R5D蛋白发生交叉反应。该单克隆抗体是由合成的大鼠源性的针对PP2R2A/PP2A, B55-α/PR55-α蛋白天冬氨酸（406位）的肽段免疫动物生产的。蛋白磷酸酶2A亚基B的异构体R2-α (PPP2R2A)是丝氨酸/苏氨酸蛋白磷酸酶2A(PP2A)的调节亚基B的组成部分。PPP2R2A属于调节亚基B的R2/B55/PR55家族(1)。有证据表明亚基PPP2R2A能够增强TGF-β、激活素和Nodal信号通路(7)并在细胞周期调节中发挥重要作用(2-4)。PPP2R2A/PP2A，B55-α/PR55-α异构体通过特异性的WD-40重复序列(5)和1型TGF-β受体相互作用，有助于TGF-β受体抗增殖功能的发挥(6)。

原厂资料：

Specificity / Sensitivity

PPP2R2A (2G9) Mouse mAb recognizes endogenous levels of total PPP2R2A/PP2A, B55-α/PR55-α protein. This antibody cross-reacts with overexpressed PPP2R4 and PPP2R5D proteins.

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp406 of rat PP2R2A/PP2A, B55-α/PR55-α protein.

Background

Protein phosphatase 2A subunit B isoform R2-α (PPP2R2A) is the component of regulatory subunit B of serine/threonine protein phosphatase 2A (PP2A). PPP2R2A belongs to the R2/B55/PR55 family of regulatory subunit B (1). Evidence suggests that subunit PPP2R2A enhances TGF-β, Activin, and Nodal signaling pathways (7) and may play an important role in cell cycle regulation (2-4). PPP2R2A/PP2A, B55-α/PR55-α isoform interacts with the type I TGF-β receptors via unique WD-40 repeats (5) that contribute to the anti-proliferative function of TGF-β receptors (6).

注意事项：

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150
mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02%
sodium azide. Store at –20°C. Do not aliquot the antibody